Effects of Postnatal Chlorpromazine on Discrimination in Rats
- 1 April 1964
- journal article
- research article
- Published by SAGE Publications in Perceptual and Motor Skills
- Vol. 18 (2) , 329-332
- https://doi.org/10.2466/pms.1964.18.2.329
Abstract
Rats treated chronically with 2 mg/kg chlorpromazine from 3 days to 60 days of age, and simultaneously exposed in their home cages to 2 geometric forms (circle and triangle), were significantly inferior to saline-treated controls in their ability at maturity to learn discriminated avoidance responses involving the forms. Chlorpromazine-treated Ss were essentially similar in discrimination learning ability to rats which were not exposed to the forms in early life. The results were interpreted as supporting an hypothesis that chlorpromazine reduces responsiveness to environmental cues by reducing sensory stimulation in general.Keywords
This publication has 6 references indexed in Scilit:
- Chlorpromazine as an Inhibitor of Brain CholinesterasesActa Pharmacologica et Toxicologica, 2009
- Multiple Range Tests for Correlated and Heteroscedastic MeansBiometrics, 1957
- Advantage of early over late perceptual experience in improving form discrimination.Canadian Journal of Psychology / Revue canadienne de psychologie, 1956
- The effect of prolonged exposure to visually presented patterns on learning to discriminate them.Journal of Comparative and Physiological Psychology, 1956
- Influence of early experience on maze-learning with and without visual cues.Canadian Journal of Psychology / Revue canadienne de psychologie, 1955
- The effect of early perceptual learning on the behavioral organization of adult rats.Journal of Comparative and Physiological Psychology, 1954