Hormones and Pulmonary Effects of Tobacco

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Abstract
Progesterone (1 to 5 mg/kg) administered subcutaneously, daily for seven days, altered the pulmonary response of the anesthetized rat. There was a reduction or blockade of bronchoconstrictor responses to the following procedures: inhalation of cigarette smoke and intravenous injection of nicotine, acethylcholine, and histamine. On the other hand, bronchodilator responses to cigarette smoke and isoproterenol hydrochloride were not influenced by progesterone. The relation of these observations to antiemphysematous action of progesterone requires further investigation.