The Choice of Drugs for Schizophrenia

Publisher Website
Google Scholar
Abstract
Schizophrenia is a serious chronic illness that requires lifelong medication. In some patients, the illness is refractory to even highly effective medications such as clozapine, and these patients desperately need more effective treatment regimens. Less dopamine is blocked with clozapine than with other antipsychotic medications, and adding more potent dopamine-blocking drugs, such as risperidone, to clozapine may achieve better efficacy. Three randomized, controlled trials examined the strategy of adding risperidone to clozapine for patients whose illness is refractory to treatment with clozapine alone. In this issue of the Journal, Honer et al.1 report the results of a trial supported by . . .