Characterization of "Peak E," a Novel Amino Acid Associated with Eosinophilia-Myalgia Syndrome
- 21 December 1990
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 250 (4988) , 1707-1708
- https://doi.org/10.1126/science.2270484
Abstract
Epidemiologic studies strongly associate eosinophilia-myalgia syndrome (EMS) with ingestion of tryptophan containing a contaminant ("peak E"). Prior reports have suggested that peak E is the di-tryptophan Nα-animal of acetaldehyde. Spectral and chemical studies now demonstrate that peak E is 1,1′-ethylidenebis[tryptophan]. This novel amino acid may be the etiological agent responsible for EMS, or it may be a marker of a still unidentified causal agent.This publication has 7 references indexed in Scilit:
- The Cause of the Eosinophilia–Myalgia Syndrome Associated with Tryptophan UseNew England Journal of Medicine, 1990
- Eosinophilia-Myalgia SyndromeJAMA, 1990
- Eosinophilia-myalgia syndrome. Results of national surveillanceJAMA, 1990
- An Investigation of the Cause of the Eosinophilia–Myalgia Syndrome Associated with Tryptophan UseNew England Journal of Medicine, 1990
- Eosinophilia-myalgia syndrome associated with exposure to tryptophan from a single manufacturerJAMA, 1990
- Efficient Synthesis of 1,1'-Methylenebis-1H-pyrrole DerivativesHETEROCYCLES, 1985
- The identity of piptamine and ormosanine, and the structures of ormojanine, ormosinine and panamineTetrahedron, 1965