Site-specific disulfide bridges in oligodeoxyribonucleotide duplexes containing 6-mercaptopurine and 4-thiothymine bases
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 9,p. 779-780
- https://doi.org/10.1039/c39930000779
Abstract
A self complementary oligodeoxynucleotide duplex containing 6-thio-2′-deoxyinosine and 4-thio-2′-deoxythymidine undergoes cross-linking to form interstrand disulfide bridges under aerobic conditions; the reaction is reversed by dithiothreitol.Keywords
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