Industrial production of monoclonal antibodies and therapeutic proteins by dialysis fermentation
- 1 May 1990
- journal article
- conference paper
- Published by Springer Nature in Cytotechnology
- Vol. 3 (3) , 295-299
- https://doi.org/10.1007/bf00365493
Abstract
A novel and powerful fermentation method is reported for the large-scale growth of mammalian cells and their secreted products. The system described illustrates many of the advantages of conventional batch fermentation processes but in addition has been shown to yield cell densities in excess of 1×107 cells/ml with concomitant increase in product concentration.Keywords
This publication has 8 references indexed in Scilit:
- Enhanced Nutrient Transport in Hollow Fiber Perfusion Bioreactors: A Theoretical AnalysisBiotechnology Progress, 1987
- Factors affecting cell growth and monoclonal antibody production in stirred reactorsJournal of Immunological Methods, 1986
- Environmental factors influencing the growth of animal cells in cultureJournal of Chemical Technology and Biotechnology, 1982
- Large-scale rotating filter perfusion system for high-density growth of mammalian suspension culturesIn Vitro Cellular & Developmental Biology - Plant, 1981
- Microencapsulated Islets as Bioartificial Endocrine PancreasScience, 1980
- Continuous cultures of fused cells secreting antibody of predefined specificityNature, 1975
- Cell Culture on Artificial Capillaries: An Approach to Tissue Growth in vitroScience, 1972
- Growth of Cell-strains and Primary Cells on Micro-carriers in Homogeneous CultureNature, 1967