“Bound” Insulin: Biologic Effects in Intact, Hypophysectomized or Adrenalectomized Rats Following Intravenous Administration
- 1 May 1966
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 78 (5) , 1079-1081
- https://doi.org/10.1210/endo-78-5-1079
Abstract
"Bound" insulin concentrates, obtained from pooled human sera, or crystalline insulin standards were injected intravenously into intact, hypophysectomized or adrenal-ectomized rats. Both "bound" and crystalline insulin, in the amounts used, caused a significant decline in the blood glucose concentrations of the hypophysectomized or adrenalectomized rats without affecting the blood glucose concentration of the intact rats. Administration of "bound" or crystalline insulin, along with trace amount of glucose -[mu]-C14 stimulated the incorporation of glucose carbon into the glycogen of the diaphragm and into the fat of the adipose tissue of hypophysectomized and adrenalectomized rats. The effects of "bound" insulin in these studies were similar to those of crystalline insulin.This publication has 4 references indexed in Scilit:
- Studies on the State of Insulin in Blood: Properties of Circulating “Free” and “Bound” InsulinEndocrinology, 1965
- Localized Intraperitoneal Action of Insulin on Rat Diaphragm and Epididymal Adipose Tissue in VivoDiabetes, 1965
- Assay of serum insulin and insulin-like activity on adipose tissue and muscle in vivoMetabolism, 1964
- STUDIES ON THE STATE OF INSULIN IN BLOOD: DISSOCIATION OF PURIFIED HUMAN BLOOD INSULIN COMPLEX(ES) BY INCUBATION WITH ADIPOSE TISSUE EXTRACTSIN VITRO1Endocrinology, 1961