Über Steroid-Konjugate in Plasma, XV. In-vivo-Biogenese von C19-Steroid-sulfatiden

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Abstract
A mixture of [7[alpha] -3H] dehydroepiandrosterone sulphate and [4-14c]-dehydroepi-androsterone were injected intravenously. Subject A received the activity ratio 3H//14C = 19. 8, subject B, 7. 7. The distribution of 3H and 14C between the various plasma steroid fractions and between the components of these fractions was measured. Under in vivo conditions, dehydroepiandrosterone sulfate appears to be preferentially converted into the sulfatide (3H/14C = 59. 8 and 103.9 respectively), but the free C19-steroids are preferentially conjugated with glucuronic acid (3H/ 14C = 3. 3 in subject B.) In the steroid sulfatide fraction, the specific radioactivity of the dehydroepiandrosterone and [DELTA]5-androstendiol-(3 [beta], 17[beta] ) is several times higher than that of the isolated andro-sterone and 5 [beta]-androstanol-(3[alpha])-one-(17). The time curve of the conversion of injected [7[alpha] -3H] dehydroepiandrosterone sulfate into labeled dehydroepiandrosterone sulfatide shows that the latter is 1st detectable after approximately 2. 5 min. The calculated half life of the sulfate is about 2 min. 40 sec., while that of the sulfatide may be considerably higher.

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