Determination of the Optimum Temperature for Regional Renal Hypothermia during Temporary Renal Ischaemia

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Abstract
Summary: To determine the optimum temperature at which the in situ kidney should be maintained while it is ischaemic, 47 mongrel dogs were studied.35 of these underwent 90 minutes of left renal ischaemia with the kidney temperature maintained at 37°, 30°, 22°, 15°, 10°, 5° and 0° C respectively.The effect on renal function was determined by measurements of G.F.R. before and at regular 15‐minute intervals after the ischaemic period. Computer statistical analysis exposed the optimum temperature to be 15° C.Renal artery blood flow, renal histology, 51Cr labelled platelets and renal arteriography were used to determine the mechanism of ischaemic injury.Quantitation of renal cell injury confirmed that no additional protection to ischaemia could be gained by cooling below 15° C.15° C is recommended as the optimum temperature for use in clinical renal hypothermia.

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