RNAi and Heterochromatin--a Hushed-Up Affair
- 13 September 2002
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 297 (5588) , 1818-1819
- https://doi.org/10.1126/science.1075874
Abstract
Sometimes it is necessary to silence genes, a process that involves shutting down regions of active chromatin. Genes can be silenced by methylation of lysine 9 in histone H3 of chromatin, but RNAi also turns out to be important in chromatin-based gene silencing. In a Perspective, Robin Allshire discusses new work (Volpe et al.) that shows how RNAi is able to shut down chromatin in fission yeast by promoting H3 lysine 9 methylation, perhaps by altering the recruitment of enzymes that methylate DNA and histones.Keywords
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