ANTI‐C‐CARBOHYDRATE ANTIBODIES AFTER PNEUMOCOCCAL VACCINATION

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Abstract
Similar levels of naturally occurring anti‐pneumococcal C‐carbohydrate antibodies were found in 15 splenectomized children, 10 splenectomized adults and 12 healthy adult volunteers by enzymelinked immunosorbent assay. Vaccination with a 14‐valent pneumococcal capsular polysaccharide vaccine (Pneumovax©) that contains approximately 75 μg C‐carbohydrate per dose only led to small anti‐C‐carbohydrate antibody increases; they were significant, however, for all three groups (p < 0.05) but antibody fold increases were below 2 in 34 of the 37 individuals studied.