Some Pharmacological Properties of 5-Chloro-2,4-Disulphamyltoluene “Disamide” an Orally Active Diuretic Agent

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Abstract
5‐Chloro‐2,4‐disulphamyl toluene, “Disamide”, is a non toxic orally active diuretic agent which has been compared with acetazolamide and chlorothiazide. Disamide at half the dose of chlorothiazide caused a greater diuresis and Na+excretion but had a slightly less Cl−excretion. The carbonic anhydrase inhibitory activity was 0.4 times that of acetazolamide but unlike the latter Disamide still caused diuresis after prolonged administration. Disamide and chlorothiazide were found to have no effect on blood pressure or respiration. The anti‐convulsant activity in mice is similar to acetazolamide. The new diuretic agent has no antibacterial, hypoglycaemic or analgesic properties.

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