Further Studies on Lipid-Chemical Differences Between Cancerous and Adenomatous Polypous Tissues in the Human Large Intestine

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Abstract
Seventeen cases of cancer and 18 cases of adenomatous polyp in the large intestine were subjected to lipid-chemical studies of their tissues to clarify the biochemical differences between malignant neoplastic growth and benign growth. Cancerous and adenomatous polypous tissues were collected by biopsy or surgery, together with the respective control tissues. One part of the total lipid extracted from each tissue was separated into triglyceride and phospholipid fractions by TLC. The fatty acid composition and content of each lipid fraction were measured by GLC. When the fatty acid composition of phospholipid was expressed in terms of the deviation rate, that of C14:0 was increased and that of C20:4 was decreased in the cancerous cases as compared with the respective values of adenomatous polyps. More definite differences were recognized between the cancerous cases and adenomatous polyps, when the ratio of the deviation rate of C14:0 to that of C20:4 was calculated in each case. The ratios distributed between 2.064 and 4.125 in 10 cancerous cases, and between 0.393 and 1.856 in 16 adenomatous polyps, indicating the biochemical differences between cancerous tissues and adenomatous polypous tissues.