A catalytic asymmetric synthesis of α-methylene lactones by the palladium-catalysed carbonylation of prochiral alkenyl halides
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 22,p. 1593-1595
- https://doi.org/10.1039/c39910001593
Abstract
A catalytic asymmetric synthesis of the α-methylene lactones starting with the prochiral alkenyl halides 8 and 19 has been achieved for the first time, giving 9 in 57% enantiomeric excess (e.e.) and 20 in 39% e. e., respectively.Keywords
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