A METHOD FOR ACHIEVING RAPIDLY STEADY-STATE BLOOD CONCENTRATIONS OF I.V. DRUGS *

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Abstract
The theoretical basis of a pharmacokinetic method to rapidly obtain and maintain a steady plasma concentration of an i.v. drug is described. Computer simulations of morphine disposition in man, using pharmacokinetic constants obtained from the literature, are provided as examples of steady-state dose regimens. The usefulness and potential limitations of the method are discussed.

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