PYRROLNITRIN ANALOGS .9. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 1-TOLYL-3-NITROPHENYL-5-METHYLPYRAZOLE-4-CARBOXYLIC ACIDS AND 1-TOLYL-3-METHYL-5-NITROPHENYLPYRAZOLE-4-CARBOXYLIC ACIDS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 39  (10) , 888-900
Abstract
The syntheses of all the possible 1-tolyl-3-nitrophenyl-5-methylpyrazole-4-carboxylic acids, 1-tolyl-5-methyl-5-nitrophenylprazole-4-carboxylic acids and of the corresponding carboxylates, are reported. Several 1,3- and 1,5-diarylpyrazole derivatives were subjected to in vitro antibacterial screenings. Some acids showed activity against some strains of gram-positive bacteria [Bacillus subtilis, B. megaterium, Sarcina lutea and Staphylococcus aureus]. The results are discussed on the basis of structure-activity relationships.

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