Malignant transformation by the DNA-protein crosslinking agent trans-Pt(II) diamminedichloride

1 December 1980

journal article
research article
Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research

Vol. 1 (12) , 989-994
https://doi.org/10.1093/carcin/1.12.989

Abstract

Trans-Pt(II) diamminedichloride (trans-Pt) produced high levels of DNA-protein crosslinks in mouse C3H-10T1/2 cells and mouse 3T3 cells. Trans-Pt induced malignant transformation in these cell types at all doses tested. In 10T1/2 cells trans-Pt induced moderate levels of transformation similar to that induced by equitoxic doses of X-rays. Trans-Pt did not act as a tumor promoter and enhance the transformation frequency seen with X-rays when cells were irradiated and then treated with this agent.

Keywords

This publication has 3 references indexed in Scilit:

Mutagenicity, cytotoxicity and DNA crosslinking in V79 Chinese hamster cells treated with cis- and trans-Pt(II) diamminedichloride
Mutation Research/Genetic Toxicology, 1979
Tumor promoter induces sister chromatid exchanges: relevance to mechanisms of carcinogenesis.
Proceedings of the National Academy of Sciences, 1978
KINETICS OF FORMATION AND DISAPPEARANCE OF A DNA CROSS-LINKING EFFECT IN MOUSE LEUKEMIA-L1210 CELLS TREATED WITH CIS-DIAMMINEDICHLOROPLATINUM .2. AND TRANS-DIAMMINEDICHLOROPLATINUM(II)
1978