Alterations in Brain Norepinephrine Metabolism Induced by Environmental Stimuli Previously Paired with Inescapable Shock
- 5 September 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 209 (4461) , 1138-1140
- https://doi.org/10.1126/science.7403874
Abstract
Footshock stress produced an immediate increase in brain concentrations of 3-methoxy-4-hydroxyphenylglycol sulfate (MHPG-SO 4 ), a major metabolite of the neurotransmitter norepinephrine, in the rat brain. Twenty-four hours after footshock stress, when concentrations had returned to baseline, increases in MHPG-SO 4 and emotional behavior could be elicited by previously neutral environmental stimuli that had been paired with the stress.Keywords
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