An Evidence-Based Review of the Efficacy of Antihistamines in Relieving Pruritus in Atopic Dermatitis

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Abstract
ATOPIC dermatitis is a common chronic or relapsing eczematous dermatitis characterized by intense pruritus and occurring primarily in infants and children with a personal or family history of atopy. Nine percent to 12% of all children are affected with atopic dermatitis,1,2 and 60% to 70% of those with mild to severe dermatitis will continue to experience symptoms into adulthood.3,4 A significant proportion of patients who have outgrown the typical manifestations of the disease develop irritant dermatitis, which may be chronic and work-disabling, especially in the context of wet, dirty, or caustic conditions.5