Crossing the Species Barrier — One Small Step to Man, One Giant Leap to Mankind

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Abstract
On first setting foot on the moon, Neil Armstrong famously proclaimed that he had taken “One small step for man, one giant leap for mankind.” With minor adjustments, he could have been referring to one of the most important distinctions between limited outbreaks of infectious diseases and the occurrence of devastating pandemics: one small step to man, one giant leap to mankind. Recent events, such as the reports of cases of avian influenza and monkeypox in humans and the outbreak of severe acute respiratory syndrome (SARS), bring this distinction into sharp focus.

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