Comparison of the Thrombotest with the One-Stage Prothrombin Time

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Abstract
THE one-stage prothrombin time was developed to serve as a diagnostic tool and was initially employed to study the bleeding state that was frequently encountered postoperatively in the jaundiced patient.1 A sequence to this investigation was the finding that the prothrombin time was increased in vitamin K deficiency and in poisoning from spoiled sweet-clover hay.2 As a result of these observations, as well as because of the simplicity of the procedure, the test was immediately employed to control dosage when bishydroxycoumarin was introduced into therapy.3 , 4 Before this new use the test had been perfected by the preparation of a thromboplastin . . .