MELANESIANS AND POLYNESIANS SHARE A UNIQUE ALPHA-THALASSEMIA MUTATION
- 1 January 1985
- journal article
- research article
- Vol. 37 (3) , 571-580
Abstract
Several genetic markers that provide information on population migrations and affinities were detected by studies of proteins and cellular antigens in blood. Analysis of DNA polymorphisms promises to yield many further population markers, and the distribution of a new .alpha.-globin gene deletion (-.alpha.3.7III) detected by a restriction enzyme mapping is reported. This is found frequently in Melanesians and Polynesians but not in 5 other populations in which .alpha.-thalassemia is prevalent. Restriction enzyme haplotype analysis was used to support a single origin for this mutation and it could be a useful population marker. Its geographical distribution supports a route through Island Melanesia for the colonizers of Polynesia.This publication has 31 references indexed in Scilit:
- Micronesian Prehistory: An Archeological OverviewScience, 1983
- A novel α-globin gene arrangement in manNature, 1980
- Haemoglobin J Tongariki is associated with α thalassaemiaNature, 1978
- Localization of the human α-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assayCell, 1977
- Alpha thalassemia in American-born Filipino infantsThe Journal of Pediatrics, 1975
- Occurrence of Heterozygotes and Homozygotes for the α-Chain Haemoglobin Variant Hb-J(Tongariki) in New GuineaNature, 1972
- Haemoglobin J Tongariki (alpha-115 alanine--aspartic acid): the first new haemoglobin variant found in a Pacific (Melanesian) population.Journal of Medical Genetics, 1967
- On the Distribution of the Gc Variant Gc Aborigine in Melanesian Populations; Determination of Gc-Types in Sera from Tongariki Island, New HebridesHuman Heredity, 1967
- Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency, Thalassaemia, and Abnormal Haemoglobins in the PhilippinesJournal of Medical Genetics, 1964
- Hæmoglobin of New-born Infants in IndonesiaNature, 1959