The Effect of Hydroxymethanesulphonate on Photosynthesis inChlorella pyrenoidosa

Abstract
Photosynthesis under conditions known to favour glycollate excretion by algae did not result in glycollate excretion in a strain of Chlorella pyrenoidosa unless an inhibitor of glycollate oxidase, α-hydroxypyridin-2yl-methane sulphonate (α-HPMS), was present. This inhibitor increased the total amount of glycollate present in the supernatant from the cells during photosynthetic carbon dioxide fixation and gave accumulation of 14C in glycollate during 14CO2 fixation under conditions favouring glycollate synthesis. At pH 8.3 α-HPMS did not stimulate photosynthetic 14CO2 fixation in C. pyrenoidosa as occurs with some algae. Photoassimilation of acetate was inhibited by α-HPMS, and this was shown to result from acetyl-CoA synthetase inhibition by α-HPMS.

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