Nonketotic hyperglycinemia
- 1 February 1993
- journal article
- case report
- Published by Wolters Kluwer Health in Neurology
- Vol. 43 (2) , 421
- https://doi.org/10.1212/wnl.43.2.421
Abstract
A 10-week-old girl with nonketotic hyperglycinemia was treated with increasing amounts of dextromethorphan, an NMDA receptor antagonist. She improved neurologically; at 35 mg/kg/d, seizures ceased and EEG normalized. Dextromethorphan withdrawal resulted in a dramatic clinical deterioration coinciding with epileptic and high-voltage slow activity in the EEG. After reintroduction of dextroinethorphan (35 mg/kg/d), recovery occurred within 24 hours.Keywords
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