The T-V 1 >T-V 6 Pattern for Electrocardiographic Diagnosis of Left Ventricular Hypertrophy and Ischemia

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Abstract
A T-wave amplitude in V1 greater than T in V6 (T-V1 T-V6) has been suggested as an early indication of left ventricular hypertrophy or myocardial ischemia. The relationship of T amplitudes in V1 and in V6 was studied in detail among 649 men and 311 women ages 20 to 60 years, free of manifest cardio-respiratory disease, and among 500 heart patients. 16% of all "healthy" men and 2% of women are found to have the syndrome T-V1 > T-V6 indicating a low specificity in men. The sex difference is one of the most striking among electro-cardiographic comparisons. Of 295 men patients with manifest heart disease of several etiologies, and otherwise normal precordial T-waves, 60% had the syndrome. Under these limited applications the syndrome gives, 60% sensitivity and 78% specificity. The T-V1 > T-V6 syndrome is therefore a weak discriminative diagnostic tool, and appears to have little prognostic value, but its presence justifies the suspicion of possible myocardial disease.