The Diagnostic Accuracy and Complications of Closed Lung Biopsies

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Abstract
The diagnostic yields and complication rates of closed lung biopsies were determined by responses to a questionnaire. Of 5,255 procedures reported, 30% were aspiration biopsies (AB), 7% tissue core biopsies (CB), 2% trephine biopsies (TR), 37% bronchial brush biopsies (BB) and 23% transbronchial biopsies (TB). Of these biopsies, 70% were done for suspected neoplasms. The diagnostic accuracy rates were: AB = 82%, CB = 84%, TR = 86%, BB = 61% and TB = 56%. Mortality rates were: AB = 0.1%, CB = 0.3%, TR = 2.9%, BB = 0.0% and TB = 0.3%. Transthoracic needle biopsies (AB, CB) had the highest overall diagnostic accuracy, with an associated low mortality and moderate morbidity.