One vs Three Years of Adjuvant Imatinib for Operable Gastrointestinal Stromal Tumor

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Abstract
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. Gastrointestinal stromal tumors are usually found in the stomach or the small intestine but can occur at any site along the gastrointestinal tract and rarely elsewhere within the abdominal cavity.1 The median age at presentation is 60 to 65 years, and the annual incidence approximately 10 cases per million.2-4 Most GISTs (75% to 80%) harbor an activating mutation in the KIT oncogene and 5% to 10% in platelet-derived growth factor receptor-α (PDGFRA), which are important for tumor molecular pathogenesis.5 The malignancy potential of GIST varies from negligible in micro GIST to aggressive cancer.6,7 Several stratification schemes are available for assessing the risk of recurrence when GIST has been resected with potential curative intent.1,2,8-10