Acute myeloid leukaemia with +i(12p) shortly after treatment of mediastinal germ cell tumour
- 1 September 1994
- journal article
- case report
- Published by Wiley in British Journal of Haematology
- Vol. 88 (1) , 196-198
- https://doi.org/10.1111/j.1365-2141.1994.tb04997.x
Abstract
We report a patient who developed acute myeloid leukaemia (M2) shortly after successful treatment of a mediastinal germ cell tumour. The leukaemia was preceded by a documented myelodysplastic phase. Complex cytogenetic abnormalities were found in bone marrow and peripheral blood cells including +i(12p), typical of germ cell malignancy. Fluorescence in situ hybridization revealed the presence of +i(12p) in myeloblasts, erythroblasts and neutrophils but not in lymphocytes. This case provides further evidence for a common clonal origin of haematological malignancies and mediastinal germ cell tumours.Keywords
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