Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor
- 1 October 1986
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 323 (6087) , 411-416
- https://doi.org/10.1038/323411a0
Abstract
Cloning and sequence analysis of DNA complementary to porcine cerebral messenger RNA encoding the muscarinic acetylcholine receptor predict the complete amino-acid sequence of this protein. Expression of the complementary DNA produces functional muscarinic receptor in Xenopus oocytes. The muscarinic receptor is homologous with the β-adrenergic receptor and rhodopsin in both amino-acid sequence and suggested transmembrane topography.Keywords
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