Human beta interferon gene localization and expression in somatic cell hybrids.
Open Access
- 1 May 1982
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 2 (5) , 564-570
- https://doi.org/10.1128/mcb.2.5.564
Abstract
The human fibroblast interferon gene beta 1 was mapped to human chromosome 9. Sequence homology with a beta 1 cDNA clone was detected in both genomic DNA and induced mRNA of human/mouse or human/hamster somatic cell hybrids containing human chromosome 9, but not in lines lacking this chromosome or those retaining a complex translocation involving chromosomes 9 and 11. Interferon mRNA that did not share sequence homology with the beta 1 cDNA clone was detected in lines containing human chromosomes 2 and 5 but lacking chromosome 9, suggesting the presence of other unlinked interferon sequences in the human genome.This publication has 22 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- Ph1-Positive Leukaemia, Including Chronic Myelogenous LeukaemiaClinics in Haematology, 1980
- Somatic Cell Genetics of Human Interferon Production in Human-Rodent Cell HybridsJournal of General Virology, 1979
- Involvement of a gene on chromosome 9 in human fibroblast Interferon productionNature, 1979
- Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.Proceedings of the National Academy of Sciences, 1979
- Fibroblast interferon in man is coded by two loci on separate chromosomesCell, 1979
- Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase IJournal of Molecular Biology, 1977
- Messenger RNA for myosin polypeptides: Isolation from single myogenic cell culturesCell, 1977
- Interferon activity produced by translation of human interferon messenger RNA in cell-free ribosomal systems and in Xenopus oöcytes.Proceedings of the National Academy of Sciences, 1975
- The Somatic Cell Genetics of Human Interferon: Assignment of Human Interferon Loci to Chromosomes 2 and 5Proceedings of the National Academy of Sciences, 1974