Procoagulant Specificity of Factor VIII Inhibitor

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Abstract
Nine hemophilia A patients with an inhibitor to factor VIII procoagulant and 8 without an inhibitor were studied for the presence of an inhibitor to von Willebrand factor (vWf) in a quantitative ristocetin-induced platelet aggregation system. The mean vWf, factor VIII related antigen (FVIII Ag) and vWf:FVIII Ag ratio were not significantly different in the 2 groups (P > 0.6). The inhibitor plasmas did not reduce the vWf level in normal plasma after a 2 h incubation. The factor VIII inhibitor is highly specific for the procoagulant function of the factor VIII complex.