Simultaneous Identification of Cocaine and Benzoylecgonine Using Solid Phase Extraction and Gas Chromatography/Mass Spectrometry
- 1 September 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 11 (5) , 233-234
- https://doi.org/10.1093/jat/11.5.233
Abstract
A procedure for the simultaneous detection and quantitation of cocaine and benzoylecgonine from urine is described. Using solid phase extraction, cocaine, benzoylecgonine, deuterated cocaine, and deuterated benzoylecgonine (2 internal standards) are extracted from urine. Benzoylecgonine and the deuterated benzoylecgonine are derivatized to their trimethylsilyl esters. The underivatized cocaine and derivatized benzoylecgonine are detected by electron impact mass spectrometry in the selected ion monitoring mode. Both cocaine and benzoylecgonine are detected at concentrations of 50 ng/mL. In addition, the procedure is simple, rapid, and suitable for a large number of specimens.This publication has 2 references indexed in Scilit:
- Routine Detection of Benzolyecgonine in Urine at a Sensitivity of 35 ng/mL by a Combination of EMIT and Gas Chromatography/Mass SpectrometryJournal of Analytical Toxicology, 1987
- Measurement of benzoylecgonine and cocaine in urine, separation of various cocaine metabolites using reversed-phase high-performance liquid chromatographyJournal of Chromatography A, 1978