DEPRESSION OF HYPOXIC PULMONARY VASOCONSTRICTION IN THE DOG BY DOPAMINE AND ISOPRENALINE

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Abstract
The effects of dopamine and isoprenaline on the pulmonary vasoconstrictor response to alveolar hypoxia were assessed by measuring the redistribution of blood flow between the lungs in response to unilateral hypoxia. Dose rates of dopamine 25 μg kg−1 min−1 and isoprenaline 0.25 μg kg−1 min−1 (which produced equal increments in the contractile force of the heart in dogs) produced a similar degree of depression of the hypoxic vasoconstrictor response, whereas dopamine 2.5 μg kg −1 min−1 had little effect on the response. PaO2 during unilateral hypoxia was inversely related to the blood flow through the hypoxic lung.