Regulation of imprinting: A multi-tiered process
- 11 November 2002
- journal article
- review article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 88 (2) , 400-407
- https://doi.org/10.1002/jcb.10352
Abstract
Although most mammalian genes are expressed from both alleles, there is a small group of special genes which are imprinted so that only one of the parental alleles is actually expressed in target cells. This epigenetic process involves regulation at a number of different stages of development and is very complex. In principle, imprinted gene regions must be marked in cis in the gametes using epigenetic features capable of being maintained through cell division and able to direct multigenic monoallelic expression in differentiated cells of the mature organism. The difference between alleles must be erased during early gametogenesis to allow the imprint to be reset in the mature gametes. In this review we will summarize what is currently known about the molecular mechanisms which mediate these steps.Keywords
Funding Information
- NIH
- Israel Cancer Research Foundation
- Israel Academy of Sciences
- Forchheimer and Belfer Foundations
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