Collagenase Production by Rheumatoid Synovial Cells: Stimulation by a Human Lymphocyte Factor
- 14 January 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 195 (4274) , 181-183
- https://doi.org/10.1126/science.188134
Abstract
Human peripheral blood lymphocytes incubated in culture for 1 to 3 days at 37°C, but not at 4°C, release a soluble factor which can stimulate, up to 400-fold, collagenase production by isolated, adherent, rheumatoid synovial cells. Production of lymphocyte factor is enhanced by phytohemagglutinin or concanavalin A. By gel filtration the factor has an apparent molecular weight of about 12,000.This publication has 16 references indexed in Scilit:
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