The Influence of Foster Nursing upon the Incidence of Spontaneous Breast Cancer in Strain C₃H Mice

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Abstract
Foster nursing of C3H $ mice (high breast-tumor line) by C57 black mice (low breast-tumor line), when the C3H young had been with their own mothers for 17 hrs. or less, lowered the incidence of spontaneous breast tumors in the C3H mice from 100% to 25%. When the foster-nursed C3H young remained with their own mothers for 24 hrs. or less, 63% developed spontaneous breast cancer. The fostered C3H mice were per- mitted to raise one litter. Foster-nursing of C57 black [female][female] by C3H mice raised the incidence of spontaneous breast tumors in the C57 black females from 1%, as reported in the literature, to 9%. The fostered C57 blacks were permitted to raise one litter. The first milk is not essential for breast tumor production in CaH [female][female] and the factor is apparently present in the C2H milk throughout the period of lactation. There is some evidence that mammary tumors appear earlier in CaH $$? when larger quantities of C3H milk are ingested during the early part of the nursing period.

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