Carcinogenicity of Ethylmethanesulfonate

Publisher Website
Google Scholar
Abstract
Sprague-Dawley rats received 3 weekly intraperitoneal injections of 33 mg ethylmethanesulfonate (EMS). None of the control animals had tumors, but 53% of the treated animals developed malignant neoplasms, most of which were anaplastic lung lesions or adenocarcinomas of the abdominal wall, comparable to adenocarcinoma of the mammary gland. A striking sex difference in tumor incidence was observed: 74% in females and 34% in males. Sixty-five percent of the EMS-treated females developed adenocarcinoma by 12 months. No renal tumors were observed, and unilateral nephrectomy did not affect the incidence of neoplasms. No differences were observed in the serum erythropoietin levels between tumor-bearing and non-tumor-bearing animals. In view of the possible use of the monoesters of methanesulfonic acid as male contraceptive agents, the potent carcinogenicity of these substances in the rat should be considered.—J Natl Cancer Inst 49: 1077–1083, 1972.

This publication has 0 references indexed in Scilit: