Rabbit Secretory IgA: Identification and Genetic Control of Two Allotypes of Secretory Component
Open Access
- 1 March 1974
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 112 (3) , 877-882
- https://doi.org/10.4049/jimmunol.112.3.877
Abstract
Two allotypes of rabbit secretory IgA have been identified with antisera obtained by cross-immunization of rabbits with secretory IgA. The two antisera, anti-t61 and anti-t62, each reacted by double diffusion analysis with secretory IgA from some but not all rabbits. Both anti-t61 and anti-t62 reacted with purified free secretory component obtained from whey. Thus, anti-t61 and anti-t62 are identifying allotypic specificities on secretory component. Genetic studies revealed that t61 and t62 are controlled by allelic genes at an autosomal locus. The t locus is not closely linked to the VHa, Cαf and Cαg (heavy chain) loci nor to the b (light chain) locus of immunoglobulins.Keywords
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