Treatment of idiopathic pituitary dwarfism with methionyl human growth hormone.

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Abstract
Patients (10) with idiopathic pituitary dwarfism were treated with methionyl human growth hormone (met-hGH) produced by recombinant DNA technology. They were given 0.5 IU/kg/wk of met-hGH for 3 mo. There were no significant changes in physical, blood, urine examinations. Their height increased between 1.5 and 2.7 cm during the 3 mo. of treatment, which was calculated to be equivalent to 6.0 and 10.8 cm/yr with a mean increase of 8.7 cm. Anti-hGH antibody was observed in all patients after 1 and 2 mo. of treatment with a titer between 101 .times. and 104 .times. .mu.M. In spite of the formation of antibodies, the growth rate did not decrease in 7 of the 10 cases.