Exposure of Newborn Rats to Pharmacologically Active Compounds May Permanently Alter Carcinogen Metabolism
- 13 February 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 211 (4483) , 719-721
- https://doi.org/10.1126/science.7455708
Abstract
Administration of phenobarbital to mother rats during early lactation causes long-term, perhaps permanent, alteration of hepatic microsomal mixed-function oxidase activity and aflatoxin B1 adduct formation in the adult male offspring. These findings suggest that perinatal exposure to pharmacologically active compounds may be a determinant of cancer risk.This publication has 14 references indexed in Scilit:
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