Hepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that contribute to the interaction
Open Access
- 1 January 2008
- journal article
- Published by Springer Nature in Virology Journal
- Vol. 5 (1) , 24
- https://doi.org/10.1186/1743-422x-5-24
Abstract
The hepatitis C virus (HCV) non-structural 5A protein (NS5A) contains a highly conserved C-terminal polyproline motif with the consensus sequence Pro-X-X-Pro-X-Arg that is able to interact with the Src-homology 3 (SH3) domains of a variety of cellular proteins.Keywords
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