Extracellular products of Staphylococcus aureus reversibly inhibit the terminal differentiation of cultured mouse epidermal cells.
- 1 January 1987
- journal article
- research article
- Published by Japan Society for Cell Biology in Cell Structure and Function
- Vol. 12 (4) , 395-399
- https://doi.org/10.1247/csf.12.395
Abstract
The effect of extracellular products from Staphylococcus aureus on the differentiation of mouse epidermal cells was studied using an in vitro cell culture system. The extracellular products from a clinical strain of S. aureus isolated from human skin lesions reversibly inhibited the Ca2+-induced terminal differentiation of epidermal cells, as determined by their morphology and the extent of cornified envelope formation. This suggests that a similar modification of cell differentiation is involved in the pathogenesis of S. aureus-induced skin disease.Keywords
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