The Stereoselective Targeting of a Specific Enzyme-Substrate Complex Is the Molecular Mechanism for the Synergic Inhibition of HIV-1 Reverse Transcriptase by (R)-(−)-PPO464
Open Access
- 1 November 2001
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 276 (48) , 44653-44662
- https://doi.org/10.1074/jbc.m106702200
Abstract
No abstract availableKeywords
This publication has 31 references indexed in Scilit:
- Resistance against Reverse Transcriptase InhibitorsClinical Infectious Diseases, 2000
- Management of the Adverse Effects of Antiretroviral Therapy and Medication AdherenceClinical Infectious Diseases, 2000
- Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active siteChemistry & Biology, 1999
- The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.Journal of Clinical Investigation, 1998
- Metabolism of the Newer AntidepressantsClinical Pharmacokinetics, 1998
- EfavirenzDrugs, 1998
- Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutionsJournal of Molecular Biology, 1997
- The Thiocarboxanilide Nonnucleoside UC781 Is a Tight-Binding Inhibitor of HIV-1 Reverse TranscriptaseBiochemistry, 1997
- BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTERAnnual Review of Biochemistry, 1993
- Generalized Equations for the Analysis of Inhibitions of Michaelis-Menten and Higher-Order Kinetic Systems with Two or More Mutually Exclusive and Nonexclusive InhibitorsEuropean Journal of Biochemistry, 1981