The chemotherapy of rodent malaria, XXIV

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Abstract
Erythromycin inhibits chloroquine-induced pigment clumping in P. berghei in vitro. The drug was tested against infections of P. berghei in mice and was active at non-toxic doses. Given orally, the stearate salt was more effective than the base, but s.c., the base was more effective than the stearate. Erythromycin potentiated the action of chloroquine against 2 chloroquine-resistant strains of rodent malaria, the mildly resistant NS, and the highly resistant RC strains of P. berghei, but not against the drug-sensitive N strain.