METABOLIC ACTIONS OF THYROXINE DERIVATIVES AND ANALOGS1

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Abstract
THERE has been a recent resurgence of interest in the chemical aspects of ‘thyroxine action. This has been largely due to the interest aroused amongst organic chemists by the discovery (1) of the high biological response to 3,5,3’-triiodothyronine (TRIT), amounting to some 4 four or more times that shown by thyroxine (2). The present report constitutes a preliminary presentation of what is hoped eventually to be the complete series of thyroxine and triiodothyronine analogs having the alanine side-chain replaced by fatty acids with one through four carbon atoms. In this study, we have determined the effects of injecting thyroxine and its analogs and derivatives on the metabolic rate of various representa- * tive tissues of the thyroidectomized rat.

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