Calculation of the Hydrophobicity of Platinum Drugs
- 30 December 2000
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 44 (3) , 472-474
- https://doi.org/10.1021/jm001080k
Abstract
Models of the hydrophobicity of platinum drugs based on exposed surface areas of polar and nonpolar atoms are presented. For a total of 24 log Poct data, the best model resulted in a standard deviation of 0.35 over a range of more than 4 log units, with regression coefficients in broad agreement with previous models of log Poct for organic molecules. This model is used to compare log Poct to cell uptake for five platinum drugs and hence to establish an exponential relation between these parameters.This publication has 10 references indexed in Scilit:
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