Antitussive activity of diphenhydramine in chronic cough

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Abstract
A double-blind crossover study was conducted to evaluate the antitussive effectiveness of diphenhydramine (DPH) in chronic coughs related to bronchitis, at doses of25 and 50 mg every 4 hr for four doses. Both 25− and 50-mg doses caused a statistically and clinically significant reduction in frequency of coughs, compared to placebo. The most frequently reported side effect was drowsiness, principally at the 50-mg dose level. There was little or no apparent correlation between antitussive effectiveness and incidence of drowsiness, however, suggesting that the two effects were pharmacologically unrelated.

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