MALE HYPOGONADISM TREATED BY SUBLINGUAL METHYLTESTOSTERONE
- 1 April 1947
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 7 (4) , 293-302
- https://doi.org/10.1210/jcem-7-4-293
Abstract
A group of 12 hypogonadal [male] [male] (10 eunuchoids, 1 castrate, 1 [male] hermaphrodite) were treated with methyltestosterone tablets especially prepared for use by the sublingual route. Each tablet contained 5 mg. of methyltestosterone; the daily requirement was from 2-6 tablets according to the needs of the patient. The subjective and objective response of these patients was similar to that obtained with injns. of testosterone propionate or implantations of testosterone pellets. This response can often be initiated or maintained on comparatively small dosage schedules. In some of these patients, the increased physical activity was at variance with the capabilities of the cardiovascular system, and the dosage was reduced accordingly; therapy was discontinued entirely in 1 case. In all cases herein reported there was definite enlargement of the phallus and scrotum. A more [male]-like growth and distribution of body hair was observed. There was increased vigor, less tendency towards fatigue and a general personality change resulting in more masculine aggressiveness.Keywords
This publication has 0 references indexed in Scilit: