Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients
- 1 February 1990
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 84 (3) , 249-252
- https://doi.org/10.1007/bf00200569
Abstract
Summary The frequency of spontaneous 6-thioguanine (TG)-resistant peripheral blood lymphocytes in five unrelated Werner syndrome (WS) patients was determined using an autoradiographic labeling assay. The average frequency of TG-resistant lymphocytes was eightfold higher in WS patients than in sex- and age-matched normal control donors. This finding and previous identification of increased spontaneous chromosomal rearrangements and deletions in WS cells or cell lines suggest that WS is a human genomic instability or mutator syndrome.Keywords
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