Sino-aortic denervation in the monkey.
- 1 March 1985
- journal article
- research article
- Published by Wiley in The Journal of Physiology
- Vol. 360 (1) , 423-432
- https://doi.org/10.1113/jphysiol.1985.sp015625
Abstract
The aortic arch and carotid sinuses were denervated in 11 monkeys [Macaca mulatta, M. fascicularis, Papio papio]. The monkeys were subjected to 4 sequential surgeries which involved implantation of an aortic and left atrial catheters, stripping of the adventitia from the aortic arch, stripping the left carotid sinus and associated vessels; and stripping the right carotid sinus and associated vessels. Blood pressure and pulse rate were recorded 6 days after each surgical procedure. Records were taken over a 6 h period while other monkeys were in their home cages. Baroreceptor denervation was confirmed by absence of heart rate response to blood pressure changes and an increase in the variability of blood pressure. Veratridine given into the left atrium caused a Bezold-Jerisch reflex both before and after denervation verifying the integrity of the afferent and effernt vagus. Denervation of the baroreceptors resulted in a significant increase in blood pressure when measured from monkeys who were restrained in chairs in the laboratory; blood pressure was not significantly elevated in the baroreceptor denervated monkeys while they they were tethered in their home cages. Evidently, denervation of the sino-aortic baroreceptor does not result in a significant increase in systemic blood pressure.This publication has 8 references indexed in Scilit:
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